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The centers

Top Mesothelioma Hospitals in America.

The United States' leading mesothelioma treatment centers — NCI-designated cancer programs and academic medical institutions that see mesothelioma every week. These are the places that combine high surgical volume, dedicated multidisciplinary teams, and active clinical trial pipelines.

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What separates a top mesothelioma hospital.

Choosing where to receive treatment is one of the most consequential decisions a newly diagnosed patient makes. These are the criteria that matter most — and the signals that distinguish an experienced program from one that sees mesothelioma only occasionally.

NCI designation

Recognized by the National Cancer Institute for research depth and patient care quality.

Dedicated team

A true multidisciplinary mesothelioma program — not a generalist oncology department.

High volume

Surgical volume correlates directly with outcomes — especially for EPP, P/D, and HIPEC procedures.

Active trials

Enrollment in current clinical trials means access to immunotherapy combinations, CAR-T, and emerging targeted therapies.

01
Pleural Research

Brigham & Women's Hospital · International Mesothelioma Program

Boston, Massachusetts

Founded by Dr. David Sugarbaker, the International Mesothelioma Program at Brigham is widely regarded as one of the most experienced mesothelioma programs in the world. The team, now led by Dr. Raphael Bueno, has published more peer-reviewed mesothelioma research than nearly any other institution globally. The program offers coordinated surgical, medical oncology, radiation, and translational research capabilities under one roof.

Notable for
Multimodal pleural surgery — one of the largest global patient volumes
Affiliated with
Harvard Medical School · Dana-Farber
02
Pleural Peritoneal HIPEC

MD Anderson Cancer Center

Houston, Texas

One of the most comprehensive mesothelioma programs in the United States, with dedicated teams for both pleural and peritoneal disease. The program integrates thoracic surgery, medical oncology, radiation, pathology, and supportive care. MD Anderson's Peritoneal Surface Malignancy program is among the highest-volume HIPEC centers in the nation, with reported 5-year survival rates above national averages.

Notable for
HIPEC for peritoneal mesothelioma — highest U.S. volume
Mesothelioma program lead
Dr. Anne Tsao
03
Pleural CAR-T Immunotherapy

Memorial Sloan Kettering Cancer Center

New York, New York

MSK's Mesothelioma Program, co-directed by Dr. Prasad Adusumilli and Dr. Michael Offin, combines one of the nation's largest mesothelioma patient volumes with cutting-edge translational research. The program was a key site in the CheckMate-743 immunotherapy trial and is actively enrolling in next-generation studies targeting BAP1 mutations, mesothelin (via CAR-T cell therapy), and TROP2-directed antibody-drug conjugates.

Notable for
Mesothelin-targeted CAR-T cell therapy research
Trial access
Active BAP1 · TROP2 · immunotherapy combinations
04
Pleural Photodynamic Proton

Penn Medicine · Abramson Cancer Center

Philadelphia, Pennsylvania

Penn Medicine's mesothelioma program is distinctive for its pioneering use of photodynamic therapy (PDT) — a light-activated drug treatment applied during surgery that has produced notable survival extensions in a subset of pleural mesothelioma patients. Penn is also a national leader in proton beam therapy and is home to Abramson Cancer Center's active thoracic oncology trials pipeline.

Notable for
Photodynamic therapy (PDT) + surgery protocol
Affiliated with
University of Pennsylvania · NCI-designated
05
Pleural Clinical trials

University of Chicago Medicine

Chicago, Illinois

The Multidisciplinary Mesothelioma Program at UChicago, directed by Dr. Hedy Kindler, is internationally recognized for clinical trial leadership. Dr. Kindler has served as principal investigator on multiple landmark trials that have introduced new drugs into the mesothelioma armamentarium. The program combines medical oncology, thoracic surgery, radiation, and translational research in a coordinated weekly tumor board model.

Notable for
Clinical trial leadership in pleural mesothelioma
Program director
Dr. Hedy Kindler
06
Pleural Lung-sparing P/D

UCLA Health

Los Angeles, California

UCLA's mesothelioma program, led by Dr. Robert Cameron, has become known nationally for its advocacy of lung-sparing pleurectomy/decortication (P/D) over the more radical extrapleural pneumonectomy (EPP) — a philosophy increasingly mirrored across U.S. centers. The program is the primary West Coast referral center for pleural mesothelioma patients.

Notable for
Lung-sparing surgical approach (P/D)
Program director
Dr. Robert Cameron
07
Pleural Robotic surgery Immunotherapy

Moffitt Cancer Center

Tampa, Florida

Moffitt is the third-largest cancer center in the United States and the only NCI-designated comprehensive cancer center based in Florida. The Mesothelioma Research and Treatment Center, directed by Dr. Jacques Fontaine, emphasizes minimally invasive and robotic surgical approaches. The program is active in novel immunotherapy-chemotherapy combination trials.

Notable for
Minimally invasive & robotic thoracic surgery
Program director
Dr. Jacques Fontaine
08
Pleural Peritoneal HIPEC

Mount Sinai · New York Mesothelioma Program

New York, New York

Directed by Dr. Andrea Wolf, Mount Sinai's program is one of the most active multidisciplinary mesothelioma practices in the Northeast. Paired with Dr. Daniel Labow's high-volume HIPEC program, Mount Sinai offers coordinated surgical and systemic care for both pleural and peritoneal mesothelioma.

Notable for
Combined pleural & peritoneal expertise
Program directors
Drs. Andrea Wolf, Daniel Labow
09
Pleural Multimodal

Baylor College of Medicine

Houston, Texas

Baylor's Mesothelioma Treatment Center, directed by Dr. Taylor Ripley, focuses on multimodal therapy integration — surgery with pre- and post-operative systemic therapy — and on outcomes research that continues to refine surgical candidate selection. Baylor works closely with the affiliated Baylor St. Luke's Medical Center.

Notable for
Multimodal therapy integration
Program director
Dr. Taylor Ripley
10
Pleural Multidisciplinary

Mayo Clinic

Rochester, Minnesota (also Phoenix & Jacksonville)

Mayo Clinic's integrated, multidisciplinary approach spans three major campuses, with mesothelioma care coordinated across thoracic surgery, medical oncology, pathology, and clinical trials. Known for same-week evaluation turnaround for referrals — a differentiator for newly diagnosed patients facing time-sensitive treatment decisions.

Notable for
Rapid multidisciplinary evaluation
Three campuses
Rochester · Phoenix · Jacksonville
11
Pleural Research

Dana-Farber Cancer Institute

Boston, Massachusetts

Closely affiliated with Brigham's surgical program, Dana-Farber handles the medical oncology and research arms of Boston's mesothelioma ecosystem. The Thoracic Oncology group is a major contributor to published clinical trial data and translational mesothelioma research.

Notable for
Thoracic medical oncology & research
Affiliated with
Harvard · Brigham & Women's
12
VA Veterans

VA Boston & VA Greater Los Angeles

Boston, MA · Los Angeles, CA

Roughly 30% of U.S. mesothelioma diagnoses are in military veterans — largely because of asbestos use in Navy ships through the 1970s. The VA Boston system (affiliated with Brigham) and VA Greater Los Angeles (affiliated with UCLA under Dr. Robert Cameron) are the two premier VA mesothelioma referral programs.

Notable for
Veterans-specific care pathways & benefits
Affiliated programs
Brigham (Boston) · UCLA (LA)

Choosing where to be treated is one of the most consequential decisions.

Talk with a patient advocate about which center fits your diagnosis, location, and insurance — and how to arrange referrals or second opinions.

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